Saturday, 11 September 2010

Inflammation linked to metabolic syndrome and mental disorders

Recent results provide evidence that link inflammation with an increased risk of metabolic syndrome and schizophrenia.1 Metabolic syndrome is characterised by central obesity, raised blood pressure, sub-optimal cholesterol and triglyceride profiles, and raised blood glucose.

In the study, white blood cell count (WBC) was determined in 199 patients. Increased WBC strongly predicted the condition of metabolic syndrome. Further significant correlations were found between high WBC and the Brief Psychiatric Rating Scale (BPRS) - a rating scale which is used to measure psychiatric symptoms such as depression, anxiety, hallucinations and unusual behaviour.

The researchers concluded that WBC can be used as a marker to predict an increased risk for metabolic syndrome and more severe psychiatric symptoms in patients with schizophrenia.

1 Fan X et al. Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia. Schizophrenia Research 118: 211-217 (2010).
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